Expert Opinion on Drug Metabolism & Toxicology

先进的药物发现技术正在使潜在的候选药物数量急剧增加。然而，这些化合物的优化越来越依赖于吸收、分布、代谢和排泄（ADME）以及毒理学（TOX）问题，这是药物发现过程中的一个主要瓶颈。在药物研究中，至少50%的药物失败被认为是由于ADME的毒性考虑。因此，在临床试验前解决药物候选药物的ADME毒性问题的能力，对于提高药物开发过程的效率和成本效益至关重要。此外，继续研究现有化合物周围的代谢、药代动力学和毒理学问题，对于优化药物方案和治疗策略具有重要意义。通过系统的审查和评估，药物代谢和毒理学专家意见提供了一个论坛，用于评论和分析ADME毒理学领域当前和新出现的研究方法，以及与特定药物或药物类别相关的代谢、药代动力学和毒理学问题。该期刊包含以下文章类型：综述----涵盖药物代谢和毒理学的各个方面，包括体外化验、体外、体内和体内的毒理学筛选，以及药物动力学研究；药物评价----评估代谢，与某一特定药物有关的药代动力学和毒理学问题；技术简介----提供对个别技术的分析，使读者全面了解所审查的具体技术；观点----突出该领域内的争议和辩论领域；会议要点----报道最近的相关会议；社论----涉及与药物代谢和毒理学有关的重要问题。听众包括保健和制药行业的科学家和管理人员、学术制药科学家和相关专业人员。

Advanced drug discovery technologies are yielding a dramatic increase in the number of potential drug candidates. However, optimisation of these compounds is becoming increasingly reliant on absorption, distribution, metabolism and excretion (ADME), and toxicological (Tox) issues, a major bottleneck in the drug discovery process. At least 50% of all drug failures in pharmaceutical research are believed to be due to ADME-Tox considerations. Therefore, the ability to solve the ADME-Tox issues of a drug candidate before clinical testing has become of utmost importance in rendering the drug development process more efficient and cost-effective. Furthermore, the continued study of metabolic, pharmacokinetic and toxicological issues surrounding existing compounds is of great importance in the optimisation of drug regimens and therapeutic strategies. Through systematic review and evaluation, Expert Opinion on Drug Metabolism & Toxicology provides a forum for the commentary and analysis of current and emerging research approaches in the ADME-Tox arena, as well as metabolic, pharmacokinetic and toxicological issues relating to specific drugs or drug classes. The journal contains the following article types: Reviews - cover every aspect of drug metabolism and toxicology including in vitro assays, toxicology screens, in vitro, in vivo and in silico ADME models, and pharmacokinetic studies; Drug Evaluations - assess metabolic, pharmacokinetic and toxicological issues related to a specific drug; Technology Profiles - provide analysis of individual technologies, offering readers a comprehensive overview of the specific technology under review; Perspectives - highlight areas of controversy and debate within the field; Meeting Highlights - provide coverage of recent related conferences; Editorials - cover important issues pertaining to drug metabolism and toxicology. The audience consists of scientists and managers in the healthcare and pharmaceutical industry, academic pharmaceutical scientists and related professionals.